POSITION DESCRIPTION: Research Scientist/Bioengineer, Stem Cell Biology
REPORTS TO: Vice President of Research and Development
CATEGORY: Full-Time Exempt
BioRestorative Therapies, Inc. develops therapeutic products using cell and tissue protocols, primarily involving adult stem cells. Our two core programs, as described below, relate to the treatment of disc/spine disease and metabolic disorders:
• Disc/Spine Program (brtxDISC™): Our lead cell therapy candidate, BRTX-100, is a product formulated from autologous (or a person’s own) cultured mesenchymal stem cells collected from the patient’s bone marrow. We intend that the product will be used for the non-surgical treatment of protruding and bulging lumbar discs in patients suffering from chronic lumbar disc disease. The BRTX-100 production process involves collecting a patient’s bone marrow, isolating and culturing stem cells from the bone marrow and cryopreserving the cells. BRTX-100 is injected by a physician into the patient’s damaged disc in an outpatient procedure. The treatment is intended for patients whose pain has not been alleviated by non-invasive procedures and who potentially face the prospect of surgery.
• Metabolic Program (ThermoStem®): We are developing an allogeneic cell-based therapy to target obesity and metabolic disorders using brown adipose (fat) derived stem cells to generate brown adipose tissue (“BAT”). BAT is intended to mimic naturally occurring brown adipose depots that regulate metabolic homeostasis in humans. Initial preclinical research indicates that increased amounts of brown fat in the body may be responsible for additional caloric burning as well as reduced glucose and lipid levels. Researchers have found that people with higher levels of brown fat may have a reduced risk for obesity and diabetes. The Company is a party to a research agreement with Pfizer with regard to the study of brown fat.
BioRestorative is seeking a candidate with a Ph.D. in biological sciences/bioengineering with an in-depth understanding of signaling pathways, as well as strong molecular and cellular biology technical skills. Experience in biologic and synthetic scaffolds, cell delivery, cell encapsulation, stem cell and adipocyte biology, epigenetic regulation of gene expression, and/or animal models of metabolic disease is preferred.
Position is available to investigate brown fat biology and regulation of whole body energy metabolism. Research will be conducted as part of a company program focused on developing cell-based therapeutics to treat metabolic disorders. Preference will be given to candidates with experience in one (or more) of the following:
Bioengineering / cell delivery / metabolism / biochemistry / physiology / experimental therapeutics / pharmacology
• Ability to initiate and complete significant experimental projects, as evidenced by publication history
• Excellent communication and organizational skills for work in a highly interactive environment
Full-time position with benefits.
Ph.D. in Biological Sciences/Bioengineering
If interested, please send your resume and compensation requirements to: firstname.lastname@example.org.